Events / Courses, Seminars & Conferences

Seminarios Internacionales de Fronteras de la Ciencia de Materiales


Javier Urraca Ruiz

Departamento de Química Analítica, Facultad de Ciencias Químicas, Universidad Complutense de Madrid

Molecular imprinting technology has evolved a great deal along its 40 years of extensive application to the synthesis of organic and hybrid materials. Conceptually, it was born to prepare synthetic materials able of mimicking the selective binding of target molecules, which is characteristic of antibodies and enzymes [1].
Molecularly imprinting allows the design and preparation of tailor-made polymer materials for (selective) recognition of chemical species. Thereby, Molecularly Imprinted Polymers (MIPs) contain specific recognition sites, with a shape and geometry of functional groups complementary to those present in the template molecule. For a MIP preparation, the selected print molecule, namely the analyte, or a surrogate molecule, interacts through covalent or non-covalent bonds with functional monomers that are polymerized in the presence of a cross-linker to form a three dimensional structure. Upon template removal, the polymer will bear specific recognition sites with complementary size, geometry and arrangement of functional groups to the target analyte. These materials have been successfully applied in several applications, such as solid-phase extraction, liquid chromatography, capillary electrophoresis, capillary electrochromatography,catalysis or as selective sorbents in chemical sensors for the determination of several families of chemical compounds, such as antibiotics, toxins, pesticides, heavy metals, peptides and proteins, among others [2,3].
In this lecture the author will present an overview of the evolution of the Molecular Imprinting technique, along the last decades and the perspectives concerning about the new synthesis formats and applications for the future.

[1] J. L. Urraca Ruiz, E. Benito Peña, M. C. Moreno Bondi, G. Orellana. Top. Curr. Chem. 2012 325: 111.
[2] J. L. Urraca, A. J. Hall, M. C. Moreno-Bondi. B. Sellergren. Angew. Chem. Int. Ed. 2006 45: 5158.
[3] J. L. Urraca, C. S. A. Aureliano, E. Schillnger, H. Esselman, J. Wiiltfang, B. Sellergren, J. Am. Chem. Soc. 2011 133: